HPLC analysis of potential COVID-19 medication | Dexamethasone

"The widely available steroid drug dexamethasone may be key in helping to treat the sickest Covid-19 patients who require ventilation or oxygen, according to researchers in the United Kingdom.
Their findings are preliminary, still being compiled and have not been published in a peer-reviewed journal -- but some not involved with the study called the results a breakthrough..."

Citation: CNN News, June 16th, 2020

See how HPLC analysis time of the two epimers (= stereoisomers that differ in configuration at only one chiral center) Dexamethasone and Betamethasone can be reduced to a fifth by using a MACHEREY-NAGEL Pentafluorophenyl core-shell silica column without loss in resolution. In comparison the same separation performed on a conventional totally porous column with the same surface chemistry.

Access to HPLC application: Dexamethasone and Betamethasone

Structure of Dexamethasone and Betamethasone


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