Chloramphenicol (CAP) is a widely used broad spectrum antibiotic in food of animal origin. It is often used as a bacteriostatic antimicrobial agent in honey production.
Its lipophilic backbone interacts with nonpolar hydrocarbon residues of the analytes while the linked hydrophilic groups interact with polar functional groups to provide enhanced retention.
Robotic sample preparation lines as well as some autosamplers are constructed that way that they lift and transport vials with a magnet the size of the vial’s cap. In these cases aluminum crimp or plastic screw caps cannot be used, as these materials won’t react to a magnet. Only metals like steel or tin will do so, however, they will also bear some problems that need to be considered.