EC HPLC column (analytical), NUCLEOSIL CHIRAL-3, 5 µm, 250x4 mm
Silica-based phase for HPLC enantiomer separation. Principle interaction modes - charge-transfer interactions, hydrogen bonds, dipole-dipole interactions and steric effects. For control of the optical purity of a substance, the two columns NUCLEOSIL CHIRAL-2 and NUCLEOSIL CHIRAL-3 allow to select conditions such that the minor enantiomer, which is present as an impurity, is eluted before the main peak. Thus, overlapping peaks are avoided. This makes an exact quantification of the impurity much easier. Based on the original NUCLEOSIL silica gel. It is one of the first spherical silicas for HPLC and was originally developed by MACHEREY-NAGEL in 1974. It is exclusively manufactured in Germany and is still one of the most used HPLC silicas in quality control around the globe.
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| Base material | NUCLEOSIL - the standard silica |
|---|---|
| Brand | NUCLEOSIL |
| Carbon content | Not available or proprietary |
| Column inner diameter | 4 mm |
| Column length | 250 mm |
| Column volume | 3.15 mL |
| Eluent in HPLC column | n-heptane – 2-propanol – TFAA (trifluoroacetic acid) (100/0.05/0.05, v/v/v) |
| Endcapped | No |
| Gross weight (incl. packaging) | 293.6 g / 0.65 lbs |
| Hardware | Stainless steel |
| Hazardous material | No |
| Method | HPLC, analytical |
| Mode | Special application or diverse |
| Packaging dimensions | 400 x 115 x 54 mm / 15.75 x 4.53 x 2.13 Inch |
| Particle shape | Spherical |
| Particle size | 5 µm |
| Particle type | Fully porous particles (FPP) |
| pH stability | 2.0–8.0 |
| Phase | NUCLEOSIL CHIRAL-3 |
| Pore size | 100 Å |
| Pressure stability (max) | 400 bar / 5800 psi |
| Recommended application(s) | Chiral, enantiomers, Control in chiral organic syntheses, Diastereomers, Enantiomers, HPLC, Pesticides, Pharmaceuticals, Propionic acid derived herbicides, Stereoisomers |
| Scope of delivery | 1x analytical HPLC column, instruction leaflet, certificate of analysis |
| Specific surface according to BET | 350 m²/g |
| Storage temperature | 15–25 °C / 59–77 °F |
| Surface chemistry | N-(3,5-dinitrobenzoyl)-L-phenylglycine (chiral selector) modification |
| Temperature stability (max) | 60 °C |
| Type | EC HPLC column (analytical) |
| USP listing | L36 |
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