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Direct Optical Resolution of a Series of Pharmacologically Active Racemic Sulphoxides by High Performance Liquid Affinity Chromatography

Method:
Matrix
Application-No.:
HPLC
-
105760

Substances: omeprazole
Column: EC 150/4 Resolvosil BSA-7
Phase: Resolvosil BSA-7
MN catalog number: 720046.40
Sample pretreatment: Sample concentration: 135 μM
Conditions: Eluent: 0.05 M phosphate buffer pH 7.9 + 2% 1-propanol 1 ml/min
Flow Rate: 1 ml/min
Injection: 20 μl
Detection
Subsequent analysis:
UV, 250 nm; 0.04 AUFS

Author(-s): Allenmark, S.; Bomgren, B.; Andersson, S.
Source: Anal. Biochem. 136 (1984) 293 - 297; J. Chromatogr. 498 (1990) 81 - 91

Keywords: enantiomers; sulfoxides
Chromatogram:


Legend: Omeprazole is trademark of AB Hässle



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