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| Spherical bulk silica packings for HPLC |
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NUCLEODUR® high purity silica
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NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties:
 Totally spherical particle shape Outstanding surface microstructure High pressure stability Low metal content |
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Summary of available NUCLEODUR® bulk packings
| Phase |
Modification |
% C |
pH range |
Particle sizes [µm] |
USP |
Structure |
| C18 HTec |
Octadecyl, high capacity, high density, endcapped |
18 |
1–11 |
5 · 7 · 10 |
L1 |
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| C18 ec |
Octadecyl, medium density, endcapped |
17.5 |
1–9 |
10 · 12 · 16
20 · 30 · 50 |
L1 |
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| SiOH |
Unmodified |
– |
2–8 |
10 · 12 · 16
20 · 30 · 50 |
L3 |
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NUCLEOSIL® standard silica
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NUCLEOSIL® is a family of totally porous spherical silicas with a very pure and uniform SiO2 structure :
Wide acceptance as routine packings for very different fields of chromatography One of the first spherical silicas used in HPLC Developed in the early seventies, now a world-renowned HPLC packing Still found in many analytical and preparative applications An absolutely reliable choice in HPLC The largest variety of modified HPLC silicas available on the market |
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Summary of available NUCLEOSIL® bulk packings
| Phase |
Modification |
Formula |
| RP phases |
| NUCLEOSIL® C18 |
Medium density octadecyl, endcapped |
-(CH2)17-CH3 |
| NUCLEOSIL® C18 AB |
Crosslinked octadecyl, endcapped, high steric selectivity |
-(CH2)17-CH3 |
| NUCLEOSIL® C8 ec |
Medium density octyl, endcapped |
-(CH2)7-CH3 |
| NUCLEOSIL® C8 |
Standard octyl, not endcapped |
-(CH2)7-CH3 |
| NUCLEOSIL® C4 |
Medium density butyl, endcapped |
-(CH2)3-CH3 |
| NUCLEOSIL® C2 |
Dimethyl |
-(CH3)2 |
| NUCLEOSIL® C6H5 ec |
Medium density phenyl, endcapped |
-(CH2)3-C6H5 |
| NUCLEOSIL® C6H5 |
Standard phenyl, not endcapped |
-(CH2)3-C6H5 |
| Phases polaires |
| NUCLEOSIL® CN |
Cyanopropyl (nitrile) |
-(CH2)3-CN |
| NUCLEOSIL® NO2 |
Nitrophenyl |
-(CH2)3-C6H4-NO2 |
| NUCLEOSIL® OH |
Diol (dihydroxypropyl) |
-(CH2)3-O-CH2-CH(OH)-CH2OH |
| NUCLEOSIL® NH2 |
Aminopropyl |
-(CH2)3-NH2 |
| NUCLEOSIL® N(CH3)2 |
Dimethylamino |
-(CH2)3-N(CH3)2 |
| NUCLEOSIL® SA |
Benzenesulfonic acid, strongly acidic cation exchanger (SCX) |
-(CH2)3-C6H4-SO3Na |
| NUCLEOSIL® SB |
Quaternary ammonium, strongly basic anion exchanger (SAX) |
-(CH2)3-C6H4-CH2-N+(CH3)3Cl– |
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| NUCLEOSIL® SiOH |
Unmodified |
(SiO2)n |
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