|
|
|
|
| Spherical bulk silica packings for HPLC |
|
| |
|
NUCLEODUR® high purity silica
|
|
|
NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties:
- totally spherical particle shape
- outstanding surface microstructure
- high pressure stability
- low metal content.
NUCLEODUR®
as a state-of-the-art silica is the ideal base material for modern HPLC
phases. It is the result of MACHEREY-NAGEL's pioneering research in
chromatography for more than 40 years.
|
|
Summary of available NUCLEODUR® bulk packings
| Phase |
Modification |
% C |
pH range |
Particle sizes [µm]
|
USP
|
Structure |
C18 ec
|
octadecyl, medium density, endcapping
|
17.5
|
1 – 9 |
10 · 12 · 16 20 · 30 · 50 |
L1 |
|
unmodified NUCLEODUR
|
· / ·
|
–
|
|
10 · 12 · 16 20 · 30 · 50 |
L3
|
|
NUCLEOSIL® standard silica
|
NUCLEOSIL® is a family of totally porous spherical silicas with a very pure and uniform SiO2 structure
- wide acceptance as routine packings for very different fields of chromatography
- one of the first spherical silicas used in HPLC
- developed in the early seventies, it became a world-renowned HPLC packing
- still found in many analytical and preparative applications
- an absolutely reliable choice in HPLC
- the largest variety of modified HPLC silicas available on the market
|
|
Summary of available NUCLEOSIL® bulk packings
Phase
|
Modification
|
Formula
|
|
RP phases
|
| NUCLEOSIL® C18 |
medium density octadecyl, endcapped
|
-(CH2)17-CH3
|
| NUCLEOSIL® C18 AB
|
crosslinked octadecyl, endcapped, high steric selectivity
|
-(CH2)17-CH3
|
| NUCLEOSIL® C8 ec |
medium density octyl, endcapped
|
-(CH2)7-CH3
|
|
NUCLEOSIL® C8
|
standard octyl, not endcapped
|
-(CH2)7-CH3
|
| NUCLEOSIL® C4
|
medium density butyl, endcapped
|
-(CH2)3-CH3
|
| NUCLEOSIL® C2
|
dimethyl
|
-(CH3)2
|
| NUCLEOSIL® C6H5 ec
|
medium density phenyl, endcapped
|
-(CH2)3-C6H5
|
| NUCLEOSIL® C6H5 |
standard phenyl, not endcapped
|
-(CH2)3-C6H5 |
| Polar phases
|
| NUCLEOSIL® CN
|
cyanopropyl (nitrile)
|
-(CH2)3-CN
|
| NUCLEOSIL® NO2
|
nitrophenyl
|
-(CH2)3-C6H4-NO2
|
| NUCLEOSIL® OH |
diol (dihydroxypropyl)
|
-(CH2)3-O-CH2-CH(OH)-CH2OH |
| NUCLEOSIL® NH2 |
aminopropyl
|
-(CH2)3-NH2 |
| NUCLEOSIL® N(CH3)2 |
dimethylamino
|
-(CH2)3-N(CH3)2 |
| NUCLEOSIL® SA |
benzenesulphonic acid, strongly acidic cation exchanger (SCX)
|
-(CH2)3-C6H4-SO3Na |
| NUCLEOSIL® SB |
quaternary ammonium, strongly basic anion exchanger (SAX)
|
-(CH2)3-C6H4-CH2-N+(CH3)3Cl– |
| |
|
|
| NUCLEOSIL® |
unmodified |
(SiO2)n
|
|
  |
|
|
 |