Silylation reagents DMCS · HMDS · TMCS · TSIM
Features

	Dimethyldichlorosilane m.w. 129.06, Bp 70 °C (760 mm Hg), density d20°/4° = 1.07	DMCS:	(CH3)2SiCl2
	used to form dimethylsilyl (DMS) derivatives DMS derivatives are much more susceptible to hydrolysis than TMS derivatives, therefore strictly anhydrous conditions during reaction are very important.
	Hexamethyldisilazane m.w. 161.4, Bp 126 °C (760 mm Hg), density d20°/4° = 0.7742	HMDS:	(CH3)3Si – NH – Si(CH3)3
	weak TMS donor; used alone reaction is slow and not very effective after addition of catalytic quantities of TMCS (e. g. 1 %) or as a mixture with TMCS (2:1, v/v; SILYL-21 and SILYL-2110) a fast and quantitative reagent for trimethylsilylation of organic compounds Aprotic solvents like acetonitrile, pyridine, dimethylformamide, carbon disulphide and dimethylacetamide are recommended for use with HMDS.
	Trimethylchlorosilane m.w. 108.7, Bp 57 °C (760 mm Hg), density d20°/4° = 0.8580	TMCS:	(CH3)3SiCl
	often used as a catalyst with other trimethylsilyl reagents Without additives it can be used for preparing TMS derivatives of organic acids. Together with methanol it can be used for methylation.
	N-Trimethylsilyl-imidazole m.w. 140.3, Bp 94 – 96 °C (760 mm Hg), density d20°/4° = 0.961	TSIM:
	strongest hydroxyl silylator; reagent of choice for carbohydrates and most steroids (even highly hindered steroids) The reagent is unique in that it reacts quickly and smooth with hydroxyl (even tert. OH) and carboxyl groups, but not with amines. This characteristic makes TSIM particularly useful in multi-derivatisation schemes for compounds with different functional groups, which are to be derivatised differently (e. g. -O-TMS / -N-HFB derivatives of catecholamines). recommended application: alcohols, phenols, organic acids, steroids, hormones, glycols, nucleotides, narcotics. For a working protocol click here.

Ordering information

	Packing unit
Code	20 x 1 ml	1 x 10 ml	5 x 10 ml	6 x 50 ml
DMCS				701230.650 *
HMDS			701240.510	701240.650 *
TMCS	701280.201 *			701280.650 *
TSIM	701310.201	701310.110	701310.510
Due to their purpose, derivatisation reagents are very reactive substances. For this reason they should be stored cool and protected from moisture. Our derivatisation reagents are supplied in vials with crimp caps for easy access with a syringe. Vials with pierced sealing disks have limited stability and should be used soon.

* in vials with crew caps