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| Silylation reagents DMCS · HMDS · TMCS · TSIM |
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Features
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Dimethyldichlorosilane
m.w. 129.06, Bp 70 °C (760 mm Hg), density d20°/4° = 1.07 |
DMCS: |
(CH3)2SiCl2 |
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Used to form dimethylsilyl (DMS) derivatives
DMS derivatives are much more susceptible to hydrolysis than TMS derivatives, therefore strictly anhydrous conditions during reaction are very important. |
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Hexamethyldisilazane
m.w. 161.4, Bp 126 °C (760 mm Hg), density d20°/4° = 0.7742 |
HMDS: |
(CH3)3Si – NH – Si(CH3)3 |
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Weak TMS donor; used alone reaction is slow and not very effective
After addition of catalytic quantities of TMCS (e.g., 1 %) or as a mixture with TMCS (2:1, v/v; SILYL-21 and SILYL-2110) a fast and quantitative reagent for trimethylsilylation of organic compounds
Aprotic solvents like acetonitrile, pyridine, dimethylformamide, carbon disulfide and dimethylacetamide are recommended for use with HMDS. |
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Trimethylchlorosilane
m.w. 108.7, Bp 57 °C (760 mm Hg), density d20°/4° = 0.8580 |
TMCS: |
(CH3)3SiCl |
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Often used as a catalyst with other trimethylsilyl reagents
Without additives it can be used for preparing TMS derivatives of organic acids.
Together with methanol it can be used for methylation. |
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N-Trimethylsilyl-imidazole
m.w. 140.3, Bp 94–96 °C (760 mm Hg), density d20°/4° = 0.961 |
TSIM: |
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Strongest hydroxyl silylator; reagent of choice for carbohydrates
and most steroids (even highly hindered steroids)
The reagent is unique in that it reacts quickly and smooth with hydroxyl (even tert. OH) and carboxyl groups, but not with amines. This characteristic makes TSIM particularly useful in multi-derivatization schemes for compounds with different functional groups, which are to be derivatized differently
(e.g., -O-TMS / -N-HFB derivatives of catecholamines).
Recommended application: alcohols, phenols, organic acids, steroids, hormones, glycols, nucleotides, narcotics. For a working protocol click here. |
Ordering information
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Packing unit |
| Code |
20 x 1 mL |
1 x 10 mL |
5 x 10 mL |
6 x 50 mL |
| DMCS 1) |
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701230.650 2) |
| HMDS 1) |
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701240.510 |
701240.650 2) |
| TMCS 1) |
701280.201 2) |
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701280.650 2) |
| TSIM |
701310.201 |
701310.110 |
701310.510 |
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| Due to their purpose, derivatization reagents are very reactive
substances. For this reason they should be stored cool and protected
from moisture. Our derivatization reagents are supplied in vials with
crimp caps for easy access with a syringe. Vials with pierced sealing
disks have limited stability and should be used soon. |
| 1) These products contain harmful substances which must be specially labeled as hazardous. For detailed information please see MSDS. |
| 2) In vials with screw caps |
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