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| HYDRODEX cyclodextrin phases |
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capillary columns for GC enantiomer separation
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Features
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base material: cyclic oligosaccharides consisting of seven (β-cyclodextrin) or eight (γ-cyclodextrin) glucose units bonded through α-1,4-linkages
regioselective derivatasation of the hydroxyl groups leads to phases with varying enantioselectivity, which are well suited for GC enantiomer analyses
Due to the high melting point of the HYDRODEX phases they are diluted with polysiloxanes for GC enantiomer separation
important advantage: many compounds can be analysed without derivatisation (however, for certain substances enantioselectivity can be favourably influenced by formation of derivatives)
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A large number of separations have been achieved, however, it is not possible to make a general prediction, which phase could solve a given separation task. Even for compounds with small structural differences or within homologous series the enantiodifferentiation can be quite different. The descriptions below list some of the typical separations possible with individual phases.
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HYDRODEX β-PM · heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin
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n = 2, R2 = R3 = R6 = methyl
phase diluted with optimised polysiloxane
recommended for hydroxycarboxylic acid esters, alcohols, diols, olefins, lactones, acetals
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max. temperature for isothermal operation 230 °C, max. temperature for short isotherms in a temperature programme 250 °C |
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HYDRODEX β-3P · heptakis-(2,6-di-O-methyl-3-O-pentyl)-β-cyclodextrin
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n = 2, R2 = R6 = methyl, R3 = pentyl
phase diluted with optimised polysiloxane
recommended for terpenes, dienes, allenes, terpene alcohols, 1,2-epoxyalkanes, carboxylic acids (esters), hydroxycarboxylic acid esters, pharmaceutics, pesticides
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max. temperature for isothermal operation 230 °C, max. temperature for short isotherms in a temperature programme 250 °C
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HYDRODEX β-6TBDM · heptakis-(2,3-di-O-methyl-6-O-t-butyldimethyl-silyl)-β-cyclodextrin
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n = 2, R2 = R3 = methyl, R6 = t-butyldimethylsilyl
phase diluted with optimised polysiloxane
recommended for γ-lactones, cyclopentanones, terpenes, esters, tartrates
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max. temperature for isothermal operation 230 °C, max. temperature for short isotherms in a temperature programme 250 °C
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HYDRODEX β-TBDAc · heptakis-(2,3-di-O-acetyl-6-O-t-butyldimethyl-silyl)-β-cyclodextrin
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n = 2, R2 = R3 = acetyl, R6 = t-butyldimethylsilyl
phase diluted with optimised polysiloxane
recommended for alcohols, esters, ketones, aldehydes, δ-lactones
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max. temperature for isothermal operation 220 °C, max. temperature for short isotherms in a temperature programme 240 °C
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HYDRODEX γ-TBDAc · NEW! octakis-(2,3-di-O-acetyl-6-O-t-butyldimethyl-silyl)-γ-cyclodextrin
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n = 3, R2 = R3 = acetyl, R6 = t-butyldimethylsilyl
phase diluted with optimised polysiloxane
recommended for cyclic ketones, aromatic ketones, oxiranes, aromatic esters, aromatic amides
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max. temperature for isothermal operation 220 °C, max. temperature for short isotherms in a temperature programme 240 °C
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Ordering information
Phase (all columns 0.4 mm OD)
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length:
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10 m
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25 m
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50 m
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ID:
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0.10 mm
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0.25 mm
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0.25 mm
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FS-HYDRODEX β-PM
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723370.25
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723370.50
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FS-HYDRODEX β-3P
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723358.25
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723358.50
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FS-HYDRODEX β-6TBDM
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723383.10
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723381.25
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723381.50
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FS-HYDRODEX β-TBDAc
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723384.25
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723384.50
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FS-HYDRODEX γ-TBDAc
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723387.25
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723387.50
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