Editors
CHROMABOND® HR-Xpert
The professional concept of innovative SPE phases
The CHROMABOND® HR-Xpert concept comprises 5 polymer-based RP and mixed-mode ion exchange phases. Depending on the character of the analytes it offers suitable adsorbents and optimal methods for sample preparation, cleaning and concentration.
The 5 CHROMABOND® HR-Xpert's are:
CHROMABOND® HR-X hydrophobic PS/DVB copolymer
CHROMABOND® HR-XC strong mixed-mode cation exchanger
CHROMABOND® HR-XA strong mixed-mode anion exchanger
CHROMABOND® HR-XCW weak mixed-mode cation exchanger
CHROMABOND® HR-XAW weak mixed-mode anion exchanger


These innovative SPE phases offer . . .
State-of-the-art spherical polymer
different particle sizes (45 µm and 85 µm) suitable for various sample volumes and matrices
broad spectrum of application with special suitability for enrichment of pharmaceuticals from biological matrices
ideal flow properties due to low content of particulate matter
Optimized pore structure and high specific surface
high loadability and outstanding elution properties in RP as well as mixed mode
low solvent consumption
rapid, economical analyses
High-purity adsorber material
allows high reproducibility with extremely low blind values
reliable analyses at ultra trace level
no method adaptation for new batches necessary


Properties and fields of application of the CHROMABOND® HR-Xpert's:
CHROMABOND® HR-X hydrophobic PS/DVB copolymer
neutral and polar active ingredients and analytes such as pesticides, drugs, phenols, PAHs, PCBs
CHROMABOND® HR-XC strong acidic mixed-mode benzenesulfonic acid cation exchanger
basic active ingredients and analytes such as amines (melamine),
. . . bases with pKa 2–10
CHROMABOND® HR-XA strong basic mixed-mode / quaternary ammonium anion exchanger
acidic active ingredients and analytes such as herbicides,
. . . acids with pKa 2–8
CHROMABOND® HR-XCW weak acidic mixed-mode / carboxylic acid cation exchanger
strongly basic active ingredients and analytes such as quaternary amines,
. . . bases with pKa > 10
CHROMABOND® HR-XAW weak basic mixed-mode / secondary/tertiary ammonium anion exchanger
strongly acidic active ingredients and analytes such as sulfonic acids, perfluorinated surfactants, . . . acids with pKa < 1


The CHROMABOND® HR-Xpert concept
for neutral, acidic and basic analytes
3 paths – 1 goal: cleaner samples
Depending on the character of the analytes HR-Xpert offers suitable adsorbents and optimal method for sample preparation, cleaning and concentration.
strong bases
pKa > 10
CHROMABOND®
HR-XCW		 acids
pKa 2–8
CHROMABOND®
HR-XA		 neutral
compounds
CHROMABOND®
HR-X		 strong acids
pKa < 1
CHROMABOND®
HR-XAW		 bases
pKa 2–10
CHROMABOND®
HR-XC
strong
bases		 acidic
compounds		 neutral
compounds*		 strong
acids		 basic
compounds
         
* under organic washing and elution conditions the following compounds will be also eluted:
HR-X: polar compounds such as organic acids and bases
HR-XC / HR-XCW: acidic components / impurities
HR-XA / HR-XAW: basic components / impurities


For standard protocols for method development with individual CHROMABOND® HR-Xpert phases please click below:
CHROMABOND® HR-X MN Appl. No. 304310
CHROMABOND® HR-XC MN Appl. No. 304790
CHROMABOND® HR-XA MN Appl. No. 304970
CHROMABOND® HR-XCW MN Appl. No. 305300
CHROMABOND® HR-XAW MN Appl. No. 305200


. . . the HR-Xpert concept guarantees:  
RP and mixed-mode SPE phases with distinct ion and RP properties
your benefit → excellent neutral, acidic and basic analytes		  
modern, spherical support polymer with optimized pore structure and high surface
your benefit → good reproducibility, reliable and cost-efficient analysis		  
possibility for more aggressive washing procedures for matrix removal
your benefit → cleaner samples and protection of your HPLC and GC instruments		  
quantification of analytes also from heavily contaminated samples
your benefit → lower limits of detection also for critical matrices		  
. . . the perfect combination for all tasks in sample preparation  

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