Editors
NUCLEODUR® high purity silica phases for HPLC
Features
NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties:
totally spherical particle shape
outstanding surface microstructure
high pressure stability
low metal content
NUCLEODUR® as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL's pioneering research in chromatography for almost 50 years.
NUCLEODUR® with 1.8 µm particle size for increased separation efficiency  


Summary of available NUCLEODUR® phases
Phase Modification % C pH range Particle sizes [µm] USP Structure
C18 Gravity octadecyl, high density coating, multi-endcapping 18 1–11 1.8 · 3 · 5 L1
C18 Gravity-SB octadecyl (monomeric), extensive endcapping
13 1–9 1.8 · 3 · 5 L1
C8 Gravity octyl, high density coating, multi-endcapping 11 1–11 1.8 · 3 · 5 L7
C18 Isis octadecyl, specially cross-linked modification, endcapped 20 1–10 1.8 · 3 · 5 L1
C18 Pyramid octadecyl with polar endcapping 14 1–9 1.8 · 3 · 5 L1
PolarTec octadecyl with embedded polar group 17 1–9 1.8 · 3 · 5 L1 L60
Phenyl-Hexyl phenylhexyl, multi-endcapping 10 1–10 1.8 · 3 · 5 L11
π2 biphenylpropyl, multi-endcapping
17 1.5–10 3 · 5 L11
PFP pentafluorophenylpropyl,
multi-endcapping
8 1–9 1.8 · 3 · 5 L43
Sphinx RP bifunctional, balanced ratio of propylphenyl and octadecyl, endcapping 15 1–10 1.8 · 3 · 5 L1 L11
C18 HTec octadecyl, high density coating, high capacity, multi-endcapping 18 1–11 1.8 · 3 · 5
7 · 10
L1
C18 ec octadecyl, medium density, endcapping 17.5
4
1–9 3 · 5
and larger
L1
C8 ec octyl, medium density, endcapping 10.5 1–9 3 · 5 L7
C4 ec butyl, medium density, endcapping 2.5 1–9 5 L26
HILIC ammonium – sulfonic acid 7 2–8.5 1.8 · 3 · 5  
CN/CN-RP cyano (nitrile) for NP and RP separations 7 1–8 3 · 5 L10
NH2/NH2-RP aminopropyl for NP and RP separations 2.5 2–8 3 · 5 L8
SiOH unmodified NUCLEODUR® 2–8 3 · 5
and larger
L3

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